Josh Simmons is out for Kansas City, and Jaylon Moore will start at left tackle with Wanya Morris in reserve. Mahomes has protected with a rotating blind side in five Super Bowls, and Moore’s first start this season adds urgency. Detroit’s secondary is decimated with four corners sidelined, though Kerby Joseph and Brian Branch are active. Taylor Decker is inactive for the Lions, amplifying concerns about pass protection. Inactives: Chiefs – Fulton, Wiley, Mitchell, Herring; Lions – Arnold, Maddox, Decker, Vaki, Cunningham, Wingo, Strickland.

The matchup hinges on Chiefs' approach to slow down Detroit’s depleted secondary and Lions’ ability to pressure Mahomes despite injuries. Fantasy angles point to Chiefs pass-catchers benefiting from quicker reads and possible red-zone opportunities, while Detroit could lean on run-heavy looks and opportunistic defense if the Chiefs protect selectively.

Xavier Worthy is active for Monday night as the Chiefs host the Jaguars after an ankle scare, with Kansas City leaning on him to lift a passing attack that welcomed his return. The Jaguars boast a stingy early-season defense that has produced three takeaways and allowed under 400 yards per game, but they’ll be without Travon Walker on the edge. Kansas City also shuffles its lineup: Omarr Norman-Lott is inactive, Mike Danna is back, and Kristian Fulton is out, underscoring the game’s fantasy implications at wide receiver and pass rush.

With Worthy ready, the Chiefs’ aerial upside rises, even as Jacksonville’s defense remains stout. The absence of Walker could tilt the balance toward the Chiefs’ passing game and open up opportunities for other KC receivers, while the Jaguars’ bottom line—few sacks allowed—puts the onus on Kansas City to win through sustainable drive progress and red-zone efficiency.

Hubbard remains the Panthers’ workhorse for Week 3, even with interior-line injuries. He should still handle the lion’s share of carries, making him a viable start in most leagues against Atlanta.

Pacheco’s early-season slump and KC’s backfield committee limit his upside, while Chubb’s return provides a steadier floor for Cleveland, though the ceiling isn’t sky-high. Use a start-sit tool to lock in Week 3 decisions.

Week 2 inactives shift Eagles depth charts dramatically. Dallas Goedert is out with a knee injury, Will Shipley rib out, Tanner McKee thumb uncertainty, Drew Kendall out, and Azeez Ojulari plus Ogbo Okoronkwo are healthy scratches again. Grant Calcaterra steps in as the starter at tight end with Kylen Granson as the other TE and Cameron Latu elevated for extra depth and potential fullback duties. Za’Darius Smith debuts for Philadelphia, while Tank Bigsby may mix in behind Barkley as A.J. Dillon contributes some offense and returns kicks.

Chiefs also lean on reinforcements with Xavier Worthy (out) and Jalen Royals out, plus Jared Wiley, Elijah Mitchell, Hunter Nourzad, and Malik Herring inactive. The mix behind Barkley features the newcomer Bigsby and veterans, potentially shifting targets away from Worthy and toward other playmakers in Kansas City. Overall, expect TE and edge rotations to heavily influence fantasy angles in this matchup.

Week 2 inactive lists for the Chiefs and Eagles were released ahead of the Arrowhead showdown. Chiefs inactive: Jalen Royals, Xavier Worthy, Jared Wiley, Elijah Mitchell, Hunter Nourzad, Malik Herring. Eagles inactive: Dallas Goedert, Azeez Ojulari, Tanner McKee, Will Shipley, Ogbo Okoronkwo, Drew Kendall.

Inactives are determined for injury status, coaching decisions, or other reasons and must be disclosed about 90 minutes before kickoff. With these absences, fantasy managers should anticipate deeper roles for reserve players and possible line and rotation changes on both sides.