Josh Simmons is out for Kansas City, and Jaylon Moore will start at left tackle with Wanya Morris in reserve. Mahomes has protected with a rotating blind side in five Super Bowls, and Moore’s first start this season adds urgency. Detroit’s secondary is decimated with four corners sidelined, though Kerby Joseph and Brian Branch are active. Taylor Decker is inactive for the Lions, amplifying concerns about pass protection. Inactives: Chiefs – Fulton, Wiley, Mitchell, Herring; Lions – Arnold, Maddox, Decker, Vaki, Cunningham, Wingo, Strickland.

The matchup hinges on Chiefs' approach to slow down Detroit’s depleted secondary and Lions’ ability to pressure Mahomes despite injuries. Fantasy angles point to Chiefs pass-catchers benefiting from quicker reads and possible red-zone opportunities, while Detroit could lean on run-heavy looks and opportunistic defense if the Chiefs protect selectively.

Xavier Worthy is active for Monday night as the Chiefs host the Jaguars after an ankle scare, with Kansas City leaning on him to lift a passing attack that welcomed his return. The Jaguars boast a stingy early-season defense that has produced three takeaways and allowed under 400 yards per game, but they’ll be without Travon Walker on the edge. Kansas City also shuffles its lineup: Omarr Norman-Lott is inactive, Mike Danna is back, and Kristian Fulton is out, underscoring the game’s fantasy implications at wide receiver and pass rush.

With Worthy ready, the Chiefs’ aerial upside rises, even as Jacksonville’s defense remains stout. The absence of Walker could tilt the balance toward the Chiefs’ passing game and open up opportunities for other KC receivers, while the Jaguars’ bottom line—few sacks allowed—puts the onus on Kansas City to win through sustainable drive progress and red-zone efficiency.

Kristian Fulton is questionable for Week 5 with a knee injury, having been limited in practice all week ahead of Monday Night Football against Jacksonville. If Fulton can’t go, Nohl Williams and Joshua Williams would handle expanded duties in KC’s secondary.

The injury introduces upside for Chiefs defenders stepping in and creates added risk around KC’s pass defense. Fantasy managers should monitor Friday’s update and be ready to adjust lineups based on Fulton’s status for the Jaguars showdown.

Van Noy's return would bolster Baltimore's edge rush in limited snaps, but hamstring risk caps his usage Sunday. The Ravens may lean on a rotating group with Likely and Stanley as day-to-day, while Jones' trend toward playing helps the interior after Madubuike and Washington were sidelined. KC comes in healthier, with Worthy set to return, though Danna and Gillotte are downgraded. Track activation and snap counts for a savvy fantasy and betting read on Week 4.