Derrick Harmon’s knee injury for the Steelers creates immediate questions about interior pass-rush depth as rosters shrink to 53 by Tuesday. Dean Lowry’s ACL concern compounds Pittsburgh’s defensive-line volatility, potentially triggering veteran market chatter or a last-minute cut-down addition. Carolina’s Brycen Tremayne flashed in a quiet WR battle, while Hunter Renfrow and David Moore remained inactive, signaling possible trades or practice-squad tinkering as the Panthers shape their 53-man plan. The upcoming slate of games and a Tuesday deadline loom large for teams sorting position battles and fantasy implications.

Beyond those headlines, teams are juggling final evaluations at edge, tackle, and back-end spots as coaches balance upside with roster certainty. The Steelers and Panthers projections will influence fantasy rosters and dynasty depth, while a bevy of Week 3 results will sharpen decisions on players who could emerge as sleepers or fade with the 53-man cuts. As color-filled rosters start to crystallize, bettors and fantasy managers will be watching how depth charts shift in the closing hours before the deadline.

In short, Week 3 underscored the delicate calculus of preseason: a single injury or inactive list can tip the scale at key spots, altering both real-game roles and fantasy upside as teams pare to 53 by Tuesday’s 4 p.m. ET cutoff.