Week 2 DFS spotlight centers on five RB matchups: Gibbs vs Bears, McCaffrey vs Saints, Conner vs Panthers, Hall vs Bills, Williams vs Cowboys. The focus is on game-script independent backs who can reach 15-20 touches regardless, a rarity in today’s NFL.

The Lions look to rebound at home while Chicago’s run defense isn’t as stout as last year. Arizona and San Francisco lean on their respective lead backs, with New York’s duo in a favorable grind. These spots fuel DFS lineups, season-long builds, and prop bets alike.

McMillan steps into Week 2 as Carolina's clear target, delivering a stable WR2 floor despite a modest Week 1. He drew 9 targets, turning them into 68 yards with elite downfield involvement (14.7 aDOT, 47.1% air yards). The matchup with Arizona is decent; Young’s early chemistry with McMillan keeps him in lineups in all formats.

The Week 1 Cardinals game plan allowed over 214 passing yards to Spencer Rattler, paving a path for McMillan to continue earning looks and maintaining volume. Expect Carolina to lean on the rookie as a primary downfield weapon, keeping McMillan firmly in the weekly WR2 mix with modest but real upside if the offense converges on rhythm.

Arizona elevates Josiah Deguara from the practice squad to serve as a fourth tight end in Week 2 against Carolina, a rare depth move for the Cardinals. With Tip Reiman sidelined and Joey Blount on IR, Deguara’s special-teams prowess and blocking know-how bolster depth while Elijah Higgins and Travis Vokolek absorb more inline duties. Expect the offense to lean on blocking and short-yardage plays, not heavy TE targets in standard leagues.

Carolina did not make roster moves, so Arizona can deploy its four-TE look with familiar pieces. For fantasy managers, monitor how much Deguara contributes on offense beyond special teams, and whether Higgins or Vokolek carve into red-zone opportunities or stay primarily blockers in Week 2.

Miami's right side is in flux as Austin Jackson lands on IR and James Daniels joins him, forcing a reshaped O-line for at least four games. Borom steps in at right tackle with Kion Smith sliding to right guard; Strange, Brunskill or Lamm may inherit later opportunities. Waller remains in the lineup with a two-TE look, and Wilson Jr. plus Patterson get practice-squad elevations to stay ready. Cornell Armstrong moves up to fifth cornerback as Bonner sits, while Wright is doubtful and Waller stays active.

Depth and tempo become the x-factors: the Dolphins will lean on internal depth, situational protection schemes, and occasional run-game adjustments against a brutal early schedule (Patriots, Bills, Jets, Panthers). The earliest Jackson or Daniels could return is Week 6 vs Chargers, giving Miami a light at the end of the tunnel as Eichenberg works off PUP. Fantasy angles hinge on who seizes the opportunistic reps along the line and how the TE and RB options are deployed in the shift.