Week 5 brought an early scare for Philadelphia as Landon Dickerson exited with a leg issue against Denver, hobbling off in the first quarter. Brett Toth stepped in to stabilize the interior as the Eagles await an official injury update, keeping an eye on how long Dickerson might be sidelined and what it means for Week 5 run and pass protection.

Fantasy angles hinge on Dickerson’s status and Toth’s surge in opportunity. A quick update could shift line stability and rushing efficiency, while continued uncertainty could tilt decisions toward Eagles RBs and protection-heavy game plans. The broader NFL injury roundup that follows underscores how fragile rosters are entering October.

Mixon remains on the Texans' non-football injury list with no firm return date, and Week 5 optimism is tempered by continued absence from practice. In shallow leagues, the prudent move is to cut or stash only in IR-enabled formats; a late-season return is far from guaranteed.

Houston leaned on rookie Woody Marks in Week 4, posting a team-high 17 carries and two scores, signaling a longer-term shift if Mixon stays out. With Mixon's future unclear, Week 5 decisions tilt toward active Texans backs and a cautious eye on Mixon's eventual role. The piece also frames Week 5 start/sit chatter among top backs for context.

Week 5 fantasy RB updates center on Bucky Irving's ankle/foot soreness for Tampa Bay, with the Buccaneers listing him as questionable. If Irving sits, Rachaad White and Sean Tucker would soak up more work. Joe Mixon is out for Week 5 in Houston, shifting backfield duties to Woody Marks with a longer term uncertainty. Jaylen Warren's Week 5 status remains murky after a knee issue, making Week 6 a key date. Tyjae Spears is expected to return within the 21 day window, potentially lifting Titans depth when activated. Miles Sanders is trending toward playing for Dallas against the Jets; Braelon Allen faces an IR path, elevating Isaiah Davis. Tyler Goodson, Sione Vaki, Kene Nwangwu, and Nathan Carter are also on the injury radar.