Joe Mixon’s 2025 season is in serious doubt after landing on the NFI-reserve list with a foot injury, leaving Houston’s backfield in flux. Week 2 pivots to Nick Chubb as the primary early-down option, with Dameon Pierce and Woody Marks providing depth behind him. For fantasy managers, Mixon’s absence means a quick roster reallocation and a shift toward safer Week 2 plays.

Owners should stash Mixon only in IR spots; otherwise, plan as if he won’t return soon. Chubb becomes the immediate focal point for Houston’s rushing attack, and the rest of the committee may carve out belt-Toyota touches. Monitor timelines and adjust lineups accordingly as updates come in.