Jalen Pitre's rib injury tests Houston's nickel defense in the MNF clash with Tampa Bay. If he rests or is limited, Derek Stingley and Kamari Lassiter must lock outside while Tremon Smith and Jaylin Smith fill depth roles, heightening Tampa Bay's passing opportunities. Houston also battles missing receivers Christian Kirk, Braxton Berrios, and center Jake Andrews, plus the absence of Joe Mixon, widening the Texans' offensive uncertainty. Tampa Bay, dealing with Luke Goedeke and Tristan Wirfs out, presses Charlie Heck into action on the right side, elevating the Buccaneers' pass protection risks.

Fantasy angles tilt toward volume and volatility. Stroud could see more targets if Houston's defense softens, while Mayfield may exploit any matchup edges with Houston’s thin back end. Will Anderson's rush becomes even more pivotal for Houston, and Danielle Hunter's presence adds to the edge pressure. Monitor Pitre's status as game time nears, since the depth players stepping up will shape weekly lineups and bets.