Following the 2025 NFL Draft, several veterans have seen their dynasty fantasy football outlooks take a hit, altering the landscape for managers. Najee Harris, who signed with the Los Angeles Chargers, has been overshadowed by the team's first-round pick, Omarion Hampton, significantly diminishing his value. Similarly, Jalen McMillan’s prospects plummeted when Tampa Bay drafted Emeka Egbuka despite McMillan's strong finish to the previous season.

Jakobi Meyers, after a career year, faces uncertain prospects with the Las Vegas Raiders, as the new regime’s first-round selection of Jack Bech signals a shift away from him. Russell Wilson, now with the New York Giants, is merely a placeholder after they drafted Jaxson Dart, casting doubt on his future. Finally, Cole Kmet's dreams of being a focal point in the Bears' offense were dashed when they selected tight end Colston Loveland with a top pick.