Las Vegas opens the 2025 season on the road vs New England with health as the key edge. Kyu Blu Kelly is expected to play after hamstring concerns, giving LV a steady starter at corner. Geno Smith anchors the offense, with Kenny Pickett as a trusted Week 1 backup after LV acquired him following O’Connell’s injury.

The Patriots enter with several injury questions, led by Christian Gonzalez (hamstring) and a handful of others limited or returning to practice. Aidan O’Connell’s earlier injury story adds context to LV’s Week 1 readiness, while Pete Carroll’s Raiders era begins with emphasis on depth, rotation, and execution.

Fantasy takeaway: Kelly’s health locks in a confident CB1/2 role for LV; Pickett’s presence could stabilize LV’s Week 1 floor while Gonzalez’s status could tilt NE’s WR matching. Expect LV’s offense to lean on Smith’s rhythm and Pickett’s veteran presence in crunch-time situational plays.

Gonzalez's hamstring may sideline him in Week 1 at Gillette, thinning the Patriots' top corner and forcing a depth-based rotation on the outside. Campbell's ankle adds uncertainty at left tackle, complicating NE's protection against a disruptive Raiders front. Barmore is listed limited but not injury-related, while Chism III is dealing with a knee issue. Charles Woods groin and Kyu Blu Kelly hamstring for Las Vegas pepper the other side of the equation, with picks and fantasy implications hinging on who steps up in coverage and in pass rush.

Thursday's notes show the Patriots leaning on depth in a potential Week 1 test, while Las Vegas adjusts around its corner injuries. For fantasy managers, the headlines point to elevated pass-game upside for Raider receivers if NE's boundary play slows, and a possible uptick in targets for Patriots wideouts if the secondary is stretched. The game shapes as a defense-and-line grind with real DFS and season-long implications depending on who can fill the missing snaps.