The Denver Broncos placed Nick Gargiulo on season-ending injured reserve after a knee injury in Saturday night’s preseason win against Arizona. Gargiulo, a 6-5, 310-pound seventh-round pick from South Carolina, was vying for a swing guard/center role before the injury ends his 2025 season prior to the 53-man roster. To fill Gargiulo’s spot on the 91-man offseason roster, Denver signed fullback Adam Prentice, a move aimed at bolstering blocking and depth behind Michael Burton and Nate Adkins, who are dealing with injuries.

Broncos injury news also includes rookie corner Joshua Pickett with a wrist/thumb issue and outside linebacker Garret Wallow leaving the game with an ankle injury. Burton (hamstring) and Adkins (ankle) were limited as the team continues to piece together its Week 1 picture. Prentice’s addition signals a depth-forward approach at the fullback/linebacker mix rather than a sweeping lineup shift, as Denver navigates roster decisions ahead of the regular season.

Fantasy managers should monitor how Denver reshapes interior-line rotation and how Prentice is used in goal-line and short-yardage plays, especially with Burton and Adkins sidelined. Gargiulo’s IR clears roster-space chatter, but the Broncos’ move to add Prentice underscores a practical, depth-conscious plan rather than a dramatic positional overhaul as the team approaches Week 1.