Jaxson Dart leads the Giants on the road in Week 4 against the Saints after a 21-18 upset of the Chargers, but the win comes with a complication: Malik Nabors is out for the season with a knee injury, forcing New York to lean more on the ground game and Dart’s mobility. Odds show New Orleans as a slight favorite at home with a 40.5-point total, while the focused game plan tilts toward a run-heavy approach in New York’s attack.

New Orleans stumbled to 0-4 but kept it close with Buffalo, suggesting a resilient defense and a capable balance when not overwhelmed by pace. The Giants’ rookie QB duel with Spencer Rattler in the Caesars Superdome shapes up as a test of improvisation and scheme, with bookmakers nudging toward the Saints. Fantasy angles hinge on depth-chart adjustments for Nabors’ absence and the Giants’ reliance on Dart’s legs and their backfield.

Two Week 4 injury reports shape the Bills-Saints fantasy outlook. Saints list Dillon Radunz out toe, Trey Palmer hamstring questionable, Devaugh Vele hip, Taliese Fuaga knee/back, Trevor Penning toe, while Cameron Jordan is active. Bills report Spencer Brown calf out, Matt Milano pectoral out, Ed Oliver ankle out, AJ Epenesa pectoral limited. These statuses could tilt which pass-catchers and backs rise for fantasy and which defenses carry upside in a Week 4 showdown.