Trevor Penning is active for Week 3 with New Orleans as the Saints battle Seattle, marking his first on-field appearance this season. Penning, shifted to guard this summer, enters a lineup hit by injuries as New Orleans eyes stability up front and a potential spark in the run game and protection. Ten players are inactive, including Taliese Fuaga and Dillon Radunz, underscoring the Saints’ depth issues heading into a hoped-for bounceback against a Seahawks club that split its first two games.

New Orleans dropped Week 1 to Arizona and Week 2 to San Francisco, while Seattle opened with a loss to San Francisco and then beat Pittsburgh. The matchup tests the Saints’ revamped interior against Seattle’s edge pressure, and Penning’s status becomes a notable fantasy storyline in a contract-year bid. After a summer buzz around his switch to guard, this is Penning’s big chance to prove himself in regular-season action.

Chase Young and Trevor Penning are ruled out for Week 1 as New Orleans hosts Arizona, reshaping the Saints' edge and left-guard rotation. Jordan Howden is listed as questionable with an oblique, while Khristian Boyd and Alontae Taylor carry limited designations; Taylor is on track to play. For Arizona, Will Hernandez is out, Calais Campbell rests, with several other Cardinals players carrying no designation. These updates tilt some Week 1 expectations on both sides and create fantasy-adjusted risk around pass rush and pass protection.

With Young and Penning sidelined, Saints' defense and offensive line faces a thinner edge presence and guard depth, while Arizona’s offensive front may benefit from an improved matchup on the Saints’ rush lanes. Fantasy implications center on QBs and pass-catchers who could see more time or time to throw, plus potential changes in defensive performance and game tempo.

Week 1 injury notes tighten fantasy decisions in the Saints–Cardinals opener. Alontae Taylor is expected to play after a groin issue, while Jordan Howden is a game-time decision in New Orleans’ safety corps. Trevor Penning is out; Chase Young is also sidelined. For Arizona, Calais Campbell and John Gaines II are set to contribute after rest, with two Cardinals questionable (Dante Stills, Owen Pappoe) and Will Hernandez ruled out. Taysom Hill and Foster Moreau remain on PUP and five Saints (Saldiveri, Clapp, Bub Means, Mason Pline, Landon Young) are done for the year on IR, shaping Week 1 lineups.

In short, Taylor’s health anchors NO’s secondary rotation, while Campbell’s activity will matter in run defense. Arizona’s rest and rest/rested players could tweak interior blocking, and the Saints’ Week 1 pass-catching and special-teams depth will be tested by missing Penning and Hill’s absence from the lineup.

Saints Week 1 intrigue centers on Alontae Taylor’s Week 1 status. Taylor returned to practice and is said to be well ahead of his groin-injury timeline, leaving a real chance he suits up versus Arizona. If he can’t go, Ugo Amadi would step in, keeping New Orleans’ corner depth intact. The development matters for fantasy defenses and pass-game planning in this opener.

Taylor posted strong numbers last season (17 games, 15 starts; 4 sacks, 89 tackles, 16 passes defended, 2 forced fumbles, 6 QB hits), underscoring his value in IDP formats and team schemes. A Week 1 absence could lift Arizona’s aerial upside and tighten Saints coverage expectations, influencing early-season DFS and season-long projections for Saints DBs and Cardinals receivers.

Saints injury updates after the Broncos game show a banged-up offensive line with Landon Young and Shane Lemieux both dealing ankle issues, Khristian Boyd with a hand, and Rico Payton sidelined with an injury that could take weeks to heal. With Trevor Penning out for the opener and Taliese Fuaga resting, New Orleans faces a depth challenge up front. Will Clapp and Nick Saldiveri suffered season-ending injuries earlier, leaving Young as a key depth option at tackle.

Fantasy managers should watch how the Saints navigate Week 1 protection and run-blocking with the reshuffled interior and tackle spots. The next few days will define which reserves emerge as reliable depth pieces and how the line’s health could influence the Saints’ early-season game plan and rushing attempts.