Saints vs Giants Week 5 injuries reshape fantasy values. Four Saints players are out, including Trey Palmer and Isaac Yiadom, with Chase Young and Cesar Ruiz also ruled out earlier. Several Saints are questionable, notably Foster Moreau, Taysom Hill, Trevor Penning, Juwan Johnson and Dillon Radunz, signaling a thinner target pool and more role rotation.

On the Giants side, Tyrone Tracy is doubtful and Dexter Lawrence is questionable as illness lingers. A handful of others are limited or questionable, including Jaxson Dart and Russell Wilson, which injects volatility into both offenses. Monitor inactives and practice reports closely as kickoff nears.

With Palmer sidelined, Saints TE usage and mid-range targets could spike if Moreau/Hill are limited. Giants’ depth on the defensive line and at QB could tilt opportunities toward secondary receivers and late-game contingency plans. Final rosters and game-day lineups will hinge on the Sunday injury reports.

Week 5's NFL slate opens amid a brutal wave of injuries shaping fantasy rosters. Tyreek Hill and Malik Nabers suffered season‑ending injuries in Week 4, shredding the Dolphins’ and Saints’ top‑end receiving darts and forcing rapid target reallocation. Purdy is sidelined with a toe, boosting Mac Jones into action for San Francisco as Jennings and Pearsall sit. Across the league, key players in every matchup are nursing bumps, with practice reports offering early clues for rostering and lineups.

In San Francisco, Purdy out and two starting receivers out, while Rob Havenstein and Tyler Higbee are doubtful for the Rams. In London, Minnesota’s J.J. McCarthy joins a Browns crew already tracking Garrett’s ankle. Dallas faces Jets with KaVontae Turpin’s status uncertain; the Ravens, Broncos, Raiders, and Saints carry their own injury narratives into Week 5, testing depth charts and daily fantasy viability.

Owners should lean into late‑week practice reports for discount targets and week‑to‑week volatility. Depth must be prioritized, with injuries often unlocking unexpected value at WR and backup RB spots. Monitor IR windows, practice participation, and ball‑carrier workload shifts as the Week 5 games approach.

Keep a close eye on Thursday Night Football notes and London‑game updates, where one injury domino can redefine projections for multiple players across fantasy leagues and betting markets.