Brock Purdy may return for the 49ers' home game against Arizona, with a turf-toe recovery that could allow limited practice this week. If he suits up, SF’s fantasy upside remains bright with Kittle and Jennings as primary targets and Tonges lurking as a Week 1 hero. In Week 2, Mac Jones orchestrated a surprising SF debut with 279 yards and 3 TDs, a sign the backup QB path can still produce fantasy dividends. Arizona starts 2-0 but hasn’t topped 300 yards in a game, hinting at potential regression as SF’s defense clamps down.

Week 1 saw Purdy deliver a late TD pass to Tonges, while Seattle loomed as the opener. The Cards’ offense, led by Kyler Murray, has been productive enough to win without explosive totals. The Week 3 clash will test Purdy’s health and the 49ers’ depth, with implications for Kittle, Jennings, Tonges and the backfield in fantasy lineups.

Week 3 survivor pools hinge on timing and edge weeks, with six games offering -5.5 or bigger spreads that beg to be played. The Bills-Dolphins Thursday game headlines the slate with Bills favored by 12, tempting some to save them for later. Savvy players look for safer edges elsewhere as the pool tightens, and R.J. White has a Week 3 pick you can view on SportsLine.

White warns against relying on any single favorite. He sees better edges among other heavy favorites and questions Seattle at 7.5 over New Orleans, despite signs from the Saints. The right Week 3 choice could decide cashing versus elimination.

Brock Purdy’s Week 3 availability is the central question for the 49ers as toe and shoulder issues collide with a home matchup against Arizona. A limited practice window keeps Purdy in play, but San Francisco has Mac Jones ready if Purdy can’t go. The team also navigates McCaffrey’s calf/rest schedule, Bosa and Williams’ vet days, and Jennings/Juszczyk injuries, while Ben Bartch lands on IR and rookie Connor Colby steps in at left guard.

Fantasy managers should monitor Purdy’s status; if he starts, the offense maintains a reasonable floor with potential upside in a plus matchup. If Jones starts, San Francisco shifts to a more conservative plan with McCaffrey as the centerpiece and Colby stabilizing the line for a run-focused attack against Arizona.

Seattle’s Week 3 status hinges on Devon Witherspoon and Nick Emmanwori not practicing Wednesday, raising questions about the boundary and safety roles against New Orleans. Mike Macdonald previously expressed optimism they could return soon, but the lack of practice time adds risk for Seattle’s secondary in a key early-season test.

From a fantasy angle, depth takes on urgency as Seattle could lean on reserve backs and safeties if the two remain limited. Monitor late-week updates for lineup decisions and DFS exposures, especially if Chicago? No, New Orleans presents a balanced attack that could test the Seahawks’ back end. Stay nimble with rosters and be ready to pivot if practice reports shift.