McCaffrey’s Week 1 workload was 31 touches, and Week 2 injury chatter centered on a calf scare. He practiced fully late in the week and wasn’t listed on the Sunday injury report, making him a strong play against New Orleans unless a late setback arises.

The 49ers’ backfield remains in flux. If McCaffrey can’t go, Brian Robinson would step into the top role and Isaac Guerendo could mix in behind him. Shanahan offered little new detail beyond saying there was nothing to report after Week 1, keeping fantasy managers on alert for last‑minute lineup decisions.

Week 2 fantasy decisions hinge on rebound potential for Pacheco, Mason, and Swift. Pacheco faces a stingy Eagles front and could see his workload grow, while Mason has momentum in Minnesota and looks poised to seize bellcow duties. Swift must translate earlier flashes into efficient carries and strong pass-game work against Detroit, still offering PPR upside.

Beyond these three, Judkins, Warren, Ridley, Odunze, Olave, Williams, and Meyers offer viable flex or streamer appeal, depending on format and roster depth. The analysis emphasizes workload, matchup, and efficiency to guide Week 2 starts and sits.

New Orleans faces a tough test as Spencer Rattler and a battered offense host San Francisco. With Taysom Hill, Foster Moreau, Trevor Penning, and potentially Taliese Fuaga sidelined, the Saints must push a more efficient passing game and smarter play design to avoid an 0-2 start.

For fantasy managers, focus on Rashid Shaheed, Chris Olave, and Alvin Kamara as the trio most likely to produce targets and yards if the Saints unlock play-action and get the ball into space. San Francisco’s defense remains elite up front and in coverage, so protection and precision from Kellen Moore and Rattler will be pivotal for any redemption day in week 2.

New England trades Ja’Lynn Polk to New Orleans and promotes Kobee Minor and Mark Robinson from the practice squad. Polk, a 2024 second-rounder, logged 12 catches for 87 yards and 2 TDs in 15 games before a shoulder injury ended his rookie season. Minor (Memphis, 2025 seventh-round) and Robinson (Pittsburgh, 2022 seventh-round) join as active players as NE heads to Miami for a pivotal Sunday matchup.

The Saints acquire Polk to bolster their WR corps, while New England leans on depth pieces on defense and special teams heading into the clash with the Dolphins at Hard Rock Stadium Sunday at 1 p.m.