Saints chase their first win of the 2025 season in Week 2 against San Francisco, with George Kittle on IR and out for at least four games, easing the 49ers’ offensive load. Purdy’s shoulder and toe injuries add doubt, meaning New Orleans could seize a path if Purdy is limited or inactive. Without Kittle, SF can lean on McCaffrey, Pearsall, and Jennings, while New Orleans focuses on its own preparation and monitoring injury updates.

Kittle’s absence sharpens the contrast between SF’s trusted playmakers and the Saints’ improving front, creating a scenarios where the result could hinge on Purdy’s health and the Saints’ ability to pressure the QB and limit the rest of SF’s weapons.