Saints host Cardinals to begin 2025, a 16-16 all-time series that leans slightly to New Orleans at home (9-4) and to the Saints in the modern Arizona era (11-6 since 1987). Murray is 1-1 vs NO with 424 yards and a TD across two clashes; Cameron Jordan has owned the matchups with five sacks in five games against Arizona. Playoff memory lingers from 2010, but recent meetings (2022: 42-34 Cards win; 2019: Saints win 31-9) suggest a high-scoring, momentum-driven start with fantasy upside on both sides.