Kyler Murray's unspecified illness adds a wrinkle to the season opener in New Orleans. Murray is expected to play, but the nagging ailment could sap his mobility and timing, boosting fantasy risk on Cardinals plays and elevating Saints defensive chances.

Brandon Staley's past success against Murray provides a Saints blueprint, even with Chase Young potentially absent, which could shift edge pressure. The outcome hinges on whether Murray can move and quicken plays while New Orleans searches for timely stops and sack opportunities.