Mac Jones arrives in San Francisco with swagger that fits Shanahan’s offense, and the 49ers want to take over the Saints’ home field in Week 2. His locker-room energy and humor have teammates buying in as the offense seeks a steady, multi-faceted attack.

Demario Davis and New Orleans aim to slow Christian McCaffrey and pressure Jones, while San Francisco expects McCaffrey to anchor a heavy-volume game plan. Fantasy angles lean toward McCaffrey’s volume and Pearsall’s growing role, with a predicted low-scoring clash that tests both defenses and play-calling limits.

McCaffrey’s Week 1 workload was 31 touches, and Week 2 injury chatter centered on a calf scare. He practiced fully late in the week and wasn’t listed on the Sunday injury report, making him a strong play against New Orleans unless a late setback arises.

The 49ers’ backfield remains in flux. If McCaffrey can’t go, Brian Robinson would step into the top role and Isaac Guerendo could mix in behind him. Shanahan offered little new detail beyond saying there was nothing to report after Week 1, keeping fantasy managers on alert for last‑minute lineup decisions.

Week 2 fantasy decisions hinge on rebound potential for Pacheco, Mason, and Swift. Pacheco faces a stingy Eagles front and could see his workload grow, while Mason has momentum in Minnesota and looks poised to seize bellcow duties. Swift must translate earlier flashes into efficient carries and strong pass-game work against Detroit, still offering PPR upside.

Beyond these three, Judkins, Warren, Ridley, Odunze, Olave, Williams, and Meyers offer viable flex or streamer appeal, depending on format and roster depth. The analysis emphasizes workload, matchup, and efficiency to guide Week 2 starts and sits.