Week 3 brings Seattle as 7.5-point favorites at home against New Orleans, but injuries to Devon Witherspoon and Nick Emmanwori could blunt Seattle’s secondary edge. Spencer Rattler and the Saints offense have found traction, and the SportsLine model assigns a 38% upset chance for New Orleans—a surprisingly credible figure for a road test. The model’s Week 3 survivor pick diverges from Seattle, suggesting a one-score outcome with Seattle at about 62% win probability.

The slate features seven 5+ point spreads, including Dolphins-Bills, Packers-Browns, Falcons-Panthers, Jets-Bucs, Saints-Seahawks, Chiefs-Giants, and Lions-Ravens, underscoring how survivor players will chase value. The model touts a long, earned track record (10,000 simulations, 37-17 on top picks since 2024) and is the guiding beacon for those locking Week 3 picks, with promos noted for new users.

Brock Purdy may return for the 49ers' home game against Arizona, with a turf-toe recovery that could allow limited practice this week. If he suits up, SF’s fantasy upside remains bright with Kittle and Jennings as primary targets and Tonges lurking as a Week 1 hero. In Week 2, Mac Jones orchestrated a surprising SF debut with 279 yards and 3 TDs, a sign the backup QB path can still produce fantasy dividends. Arizona starts 2-0 but hasn’t topped 300 yards in a game, hinting at potential regression as SF’s defense clamps down.

Week 1 saw Purdy deliver a late TD pass to Tonges, while Seattle loomed as the opener. The Cards’ offense, led by Kyler Murray, has been productive enough to win without explosive totals. The Week 3 clash will test Purdy’s health and the 49ers’ depth, with implications for Kittle, Jennings, Tonges and the backfield in fantasy lineups.