Trevor Penning's turf toe could push him out of the Saints' opener with Arizona, a matchup that now hinges on an injured interior and a shifted line. Turf toe usually heals in 4-6 weeks, placing Week 1 in doubt. If Penning sits, Dillon Radunz would slide into left guard with Kelvin Banks anchoring left tackle, a change that could temper the Saints' run game and give Arizona's revamped front a fault line to exploit. The Cards’ pressure potential heightens the fantasy stakes for Week 1, especially for Saints pass protection and short-yardage runs. Monitor Penning’s status closely, as any delay boosts Cardinals’ defensive upside and tightens Saints’ timing with a rookie QB scenario.

In this context, fantasy managers should reassess early-week plans. If Penning is out or limited, Notre Saints’ interior protection could waver, impacting Kamara’s early-season workload and the Saints’ pass rhythm. Arizona’s defensive front, refreshed this offseason, could apply more heat, elevating the floor for Cardinals’ defenders in streamer considerations. This situation also emphasizes the value of depth across the Saints’ line and backs—linemen stepping in could become pivotal in Week 1 game scripts and fantasy lineups.