Chase Young and Trevor Penning are ruled out for Week 1 as New Orleans hosts Arizona, reshaping the Saints' edge and left-guard rotation. Jordan Howden is listed as questionable with an oblique, while Khristian Boyd and Alontae Taylor carry limited designations; Taylor is on track to play. For Arizona, Will Hernandez is out, Calais Campbell rests, with several other Cardinals players carrying no designation. These updates tilt some Week 1 expectations on both sides and create fantasy-adjusted risk around pass rush and pass protection.

With Young and Penning sidelined, Saints' defense and offensive line faces a thinner edge presence and guard depth, while Arizona’s offensive front may benefit from an improved matchup on the Saints’ rush lanes. Fantasy implications center on QBs and pass-catchers who could see more time or time to throw, plus potential changes in defensive performance and game tempo.