Week 21 of 2025 in fantasy baseball tightens the waiver-wire playbook across five categories, with three under-the-radar options per category highlighted. rostered thresholds cap at 50 percent on Yahoo, encouraging strategic streaming for runs, homers, RBIs, steals and AVG as the stretch run begins. Frelick, Simpson and Varsho anchor Runs; Andujar, Sosa and Colby Thomas bring home-run upside; Steer, Gurriel Jr. and Rice offer RBI punch; Crews, Caballero and Freeman supply speed; Collins, Marte and Ortiz push batting-average help to shored up lineups.

These names are positioned to deliver immediate contributors in the coming weeks, with multi-eligibility and favorable batting-order spots cited as meaningful leverage. Managers should balance at-bats with rostership and park factors, leveraging recent two-week bursts and weekly trends to maximize category boosts as playoff races heat up.

The Diamondbacks staged a 3-2 walk-off win over the Guardians in 10 innings after Lourdes Gurriel Jr. tied the game with a ninth-inning homer. Adrian Del Castillo delivered the deciding hit in the 10th, looping a walkoff single off Matt Festa to cap Arizona’s comeback. Cleveland rookie Parker Messick settled into a strong MLB debut, tossing 6 2/3 innings and yielding just one run on seven hits while throwing 83 pitches. Cleveland had led 2-1 entering the ninth, but Gurriel’s big blast and Arizona’s late rally turned the series rubber match around.

The Guardians and Diamondbacks traded blows in a tense Game 2, with Cleveland and Arizona answering every score in a see-saw duel that swung on offense and bullpen depth. José Ramírez sparked Cleveland’s early offense with a walk that helped set up Carlos Santana’s RBI single and Nolan Jones’s run-scoring hit, while Ramírez later delivered his 26th homer of the year. Brayan Rocchio showed patience at the plate, working a six-pitch walk in a critical late-inning sequence. For Arizona, Corbin Carroll’s fourth-inning triple and Lourdes Gurriel Jr.’s late-two-RBI single flipped the script and handed the Diamondbacks a precarious lead they would hold to the finish. In a game where every rally mattered, Diamondbacks relievers navigated the eighth, while Guardians late threats fizzled with runners at the corners and two outs. For fantasy managers, this one underscored how quickly momentum can shift in a volatile ballpark series and highlighted a few players whose rosters and matchups should be weighed with priority and risk in upcoming games.

Key moments included a read-and-score sequence on a Ramírez read on a quick David Fry development, a sixth-inning stand by Cleveland’s starter Tanner Bibee before Arizona rallied, and back-to-back offensive bursts that stretched into extra innings of regulation. The Guardians showed resilience but left the decisive opportunity on the table in the eighth as Arizona closed the door. The result tightens the series to a nail-biter, with both clubs carrying impactful fantasy implications at the plate and on the mound.

Gavin Williams delivered 5 1/3 scoreless innings, fanning five and walking one, as the Cleveland Guardians snapped a three-game skid with a 3-1 win in Phoenix against the Arizona Diamondbacks. CJ Kayfus produced two hits, including a 406-foot homer in the second that gave Cleveland a 1-0 lead, and Brayan Rocchio connected for a homer in the fifth to push the cushion to 3-0. Cade Smith closed it out with a save, striking out Ketel Marte to cap the victory.

Arizona stranded 10 and went 1-for-8 with runners in scoring position, while Zac Gallen allowed three runs on five hits, including both homers, with three strikeouts and no walks. Gallen’s season has seen a career-high in homers allowed. Cleveland closed within three games of the AL wild-card cutoff. Rocchio has been heating up, hitting safely in 14 of his last 16 games with a .315 clip and nine RBIs in that span, while Kayfus has homered in both road trips since his Triple-A promotion.

EightPitch: Saturday MLB DFS pivots center on a Diamondbacks-heavy slate with Arizona projected to carry the day—their top-billed bats look prime against Chase Dollander in Denver, while the Diamondbacks’ hefty run total supports a powerful stack alongside midrange to budget sleepers. Sonny Gray anchors a Thursday-to-Saturday plan with a favorable Yankees matchup in STL, while a budget-friendly Jason Alexander provides a high-floor punt option in Houston. Langeliers, Perdomo, Caminero, Marte and Gurriel headline the infield and outfield cores, with Altuve and Simpson stepping in for value and speed. Houston and Oakland stacks also offer strong leverage spots in this nine-game DK/FD slate, which kicks off at 7:10 PM ET, weather-safe aside from Tigers–Twins risk.