The NFL schedule release is eagerly awaited, with particular excitement surrounding Buffalo Bills' matchups for the 2025 season. The Bills top NFL.com's must-watch matchups with a highly anticipated game against the Kansas City Chiefs, featuring superstar quarterbacks Josh Allen and Patrick Mahomes. With both teams having faced each other nine times since 2020, the Bills have won four consecutive regular-season meetings, but they still seek postseason victory over Mahomes' squad. This clash is pivotal for playoff seeding.

Another exciting game for the Bills is against the Cincinnati Bengals, ranked fifth on the must-watch list. This matchup promises to be a high-scoring affair, as both teams excelled offensively last season. The Bills ranked second in points scored, while the Bengals followed closely at sixth, setting the stage for another thrilling showdown.