Milano's return shores up Buffalo's defense for the Week 5 primetime clash with New England, but interior depth is thin with Ed Oliver and TJ Sanders out and Dorian Williams inactive. Landon Jackson will debut, while Zion Logue and Phidarian Mathis join the DT rotation. Curtis Samuel earns a jersey as Elijah Moore remains inactive, and Samuel/Khalil Shakir provide return opportunities with Johnson handling kicks. Jimmy Ciarlo is active after a late roster move.

Fantasy angles center on how Logue/Mathis anchor the interior and whether Jackson can spark the edge rush, plus how Samuel, Johnson, and Shakir contribute in return duties and short-yardage packages against New England.

Buffalo's Week 5 inactive list reshapes the depth chart. Dorian Williams and Dorian Strong sit out, Elijah Moore and Jordan Hancock join the bench, and Ed Oliver and TJ Sanders are sidelined on the defensive line, tangling Buffalo's fantasy floor at multiple spots. New England counters with Chaisson, Gregory, Wallace, Chism, and DeVito out, narrowing contingency plans and elevating backup options.

Patriots-Bills Week 5 inactives reshape fantasy expectations. Carlton Davis and Milton Williams are active, anchoring New England’s secondary and interior line as Jahlani Tavai returns. K'Lavon Chaisson is out, likely boosting Keion White’s rush opportunities against Josh Allen. Efton Chism III remains inactive, stalling rookie WR upside.

Bills list Elijah Moore, Ed Oliver, Dorian Williams, Jordan Hancock, Brandon Codrington, Chase Lundt, and T. J. Sanders as inactive, signaling clearer target trees and fewer interior disruptors for Buffalo. Snap and scheme shifts could tilt value on both sides, especially for edge rushers and defensive units in DFS.