Milano's return shores up Buffalo's defense for the Week 5 primetime clash with New England, but interior depth is thin with Ed Oliver and TJ Sanders out and Dorian Williams inactive. Landon Jackson will debut, while Zion Logue and Phidarian Mathis join the DT rotation. Curtis Samuel earns a jersey as Elijah Moore remains inactive, and Samuel/Khalil Shakir provide return opportunities with Johnson handling kicks. Jimmy Ciarlo is active after a late roster move.

Fantasy angles center on how Logue/Mathis anchor the interior and whether Jackson can spark the edge rush, plus how Samuel, Johnson, and Shakir contribute in return duties and short-yardage packages against New England.

Buffalo's backfield could pivot again as Brady hints at a more balanced attack beyond James Cook, who has piled up yards but needs to be kept fresh for January. Brady said he trusts Davis and Johnson, signaling a potential rotation if Cook sits or is limited late in games.

The Bills face New England's stout run defense in primetime, so expect a sharper mix of carries and screen work to keep Cook's volume sustainable while preserving a hot-hand approach for Davis and Johnson as the Bills aim for a sustained January push.

Buffalo hosts New Orleans at Highmark Stadium with the Bills as heavy favorites. Fantasy angles hinge on Josh Allen’s protection, Cook and Johnson sharing carries, Hawes expanding as a receiving option, and Rousseau pressuring the Saints’ line. New Orleans counters with Spencer Rattler’s mobility, which could create rushing yards and space for receivers, testing Buffalo’s edge.

Expect Bills to push a balanced attack and rely on a clean pocket to maximize fantasy upside; if protection slips, the ceiling drops. The Saints bring volatility with Rattler’s legs, making Saints pass-catchers and the backfield intriguing DFS plays in a potentially high-variance matchup.

Ty Johnson edged Ray Davis for more early-down work through two Bills-Dolphins weeks, hinting at a bigger handcuff role if Cook stays healthy. Ollie Gordon II carved in short-yardage and goal-line snaps for Miami, expanding Achane’s TD pathways in a tight run game. Kincaid’s fantasy role remains muddled by a three-way Bills TE rotation, but his target rate ticked up.

Achane’s season ceiling could hinge on Gordon’s usage, while Miami’s Hill, Conner and Patterson offer practical edges for Week 4 and beyond. Palmer’s 11-personnel role and Waddle’s health add nuance to both teams’ passing games for fantasy and props.