Milano's return shores up Buffalo's defense for the Week 5 primetime clash with New England, but interior depth is thin with Ed Oliver and TJ Sanders out and Dorian Williams inactive. Landon Jackson will debut, while Zion Logue and Phidarian Mathis join the DT rotation. Curtis Samuel earns a jersey as Elijah Moore remains inactive, and Samuel/Khalil Shakir provide return opportunities with Johnson handling kicks. Jimmy Ciarlo is active after a late roster move.

Fantasy angles center on how Logue/Mathis anchor the interior and whether Jackson can spark the edge rush, plus how Samuel, Johnson, and Shakir contribute in return duties and short-yardage packages against New England.

Buffalo's Week 5 inactive list reshapes the depth chart. Dorian Williams and Dorian Strong sit out, Elijah Moore and Jordan Hancock join the bench, and Ed Oliver and TJ Sanders are sidelined on the defensive line, tangling Buffalo's fantasy floor at multiple spots. New England counters with Chaisson, Gregory, Wallace, Chism, and DeVito out, narrowing contingency plans and elevating backup options.

Patriots-Bills Week 5 inactives reshape fantasy expectations. Carlton Davis and Milton Williams are active, anchoring New England’s secondary and interior line as Jahlani Tavai returns. K'Lavon Chaisson is out, likely boosting Keion White’s rush opportunities against Josh Allen. Efton Chism III remains inactive, stalling rookie WR upside.

Bills list Elijah Moore, Ed Oliver, Dorian Williams, Jordan Hancock, Brandon Codrington, Chase Lundt, and T. J. Sanders as inactive, signaling clearer target trees and fewer interior disruptors for Buffalo. Snap and scheme shifts could tilt value on both sides, especially for edge rushers and defensive units in DFS.

New England Patriots Week 5 injury report ahead of the primetime clash with Buffalo shows key questions on the edge and in the secondary. K'Lavon Chaisson knee and Jaylinn Hawkins hamstring leave both outside linebackers and safeties in flux, while Jahlani Tavai returns as a limited participant after IR. Several Patriots linemen and linebackers logged limited work, and Will Campbell came back to full participation after a shoulder issue. Bills' side lists multiple non-participants or limited players as well, setting up a high-stakes fantasy showcase.

Buffalo’s Dorian Williams knee kept him out, Matt Milano (pectoral) and Ed Oliver (ankle) were limited, Spencer Brown (calf) and Jackson Hawes (ankle) followed with limited practice. No Bills players were listed as fully participating. The Week 5 picture hinges on edge depth, LB rotation, and the health of interior lines, with fantasy managers eyeing snap shares and potential upside if injuries linger.