Brock Purdy’s turf-toe injury sidelines the 49ers QB for up to five weeks, thrusting Mac Jones into Sunday’s matchup with New Orleans. Fantasy managers should scan the QB streamer list, with Daniel Jones, Trevor Lawrence, and even Aaron Rodgers cited as viable options in tougher spots.

Week 1’s injury avalanche continued with Austin Ekeler’s season-ending Achilles and George Kittle’s hamstring. Add in Xavier Worthy’s shoulder and Brock Bowers’s knee, and the waiver wire becomes a chessboard. Watch for sleepers like Harold Fannin Jr. and Emeka Egbuka to emerge for deeper leagues.

With Xavier Worthy sidelined and Rashee Rice suspended, Tyquan Thornton steps into a bigger role as Kansas City’s vertical option. He flashed vs. the Chargers, 41 yards on four targets, signaling upside alongside Hollywood Brown. Thornton’s path from a Patriots cut to KC’s go-to deep threat adds a redemption arc for fantasy managers during Rice’s absence and Worthy’s injury, behind a Mahomes-led high-floor ceiling.

The storyline hinges on Thornton’s speed, route savvy, and how the Chiefs deploy him with Brown as a seasoned pairing. If KC leans into Thornton’s wheels, his target depth could grow quickly, turning a low-risk bench stash into a weekly flex with Deshaun-level chase urge in best-ball and DFS lineups.

Miami's right side is in flux as Austin Jackson lands on IR and James Daniels joins him, forcing a reshaped O-line for at least four games. Borom steps in at right tackle with Kion Smith sliding to right guard; Strange, Brunskill or Lamm may inherit later opportunities. Waller remains in the lineup with a two-TE look, and Wilson Jr. plus Patterson get practice-squad elevations to stay ready. Cornell Armstrong moves up to fifth cornerback as Bonner sits, while Wright is doubtful and Waller stays active.

Depth and tempo become the x-factors: the Dolphins will lean on internal depth, situational protection schemes, and occasional run-game adjustments against a brutal early schedule (Patriots, Bills, Jets, Panthers). The earliest Jackson or Daniels could return is Week 6 vs Chargers, giving Miami a light at the end of the tunnel as Eichenberg works off PUP. Fantasy angles hinge on who seizes the opportunistic reps along the line and how the TE and RB options are deployed in the shift.