Chargers Week 5 collapse amplifies injury chaos: Omarion Hampton left late in a walking boot, Mekhi Becton exited with a hand issue after a brief return from concussion protocol, and Rashawn Slater is out for the year at one tackle spot. Joe Alt sprained an ankle, Najee Harris is sidelined for the season, and the backfield depth is thin behind a banged-up line. Hassan Haskins, Kimani Vidal, and Amar Johnson sit in the wings, while questions loom about roster moves and next-week adjustments for Justin Herbert.

Fantasy managers should prepare for a committee-driven backfield and potential increased workload for Herbert as the Chargers lean on depth options and possible signings. Expect more snap share for backups and a watchful eye on practice reports as Philadelphia or other suitors could influence the roster landscape in the coming days.

James Conner is done for 2025 after a foot injury lands him on IR. Trey Benson steps into a lead role for Arizona, with Emari Demercado factoring on passing downs. Najee Harris suffers a torn Achilles for the Chargers, opening the backfield to Omarion Hampton and Kimani Vidal. Tyjae Spears could return in Week 5, though Titans will ease him in behind Pollard. Brandon Aiyuk is on PUP with a murky timeline, and Nick Bosa tears his ACL for SF, prompting Bryce Huff to rise. Stash IR targets and watch ramp-ups and backfield shifts.