Week 4 injury report for the Los Angeles Chargers is lengthy, with 10 players on the list headlined by Mekhi Becton’s concussion. Center Bradley Bozeman did not practice, and right tackle Trey Pipkins III was limited by a knee issue, raising questions about interior protection for Justin Herbert. Elijah Molden and Donte Jackson headline a developing cornerback group, while Will Dissly, Da'Shawn Hand, Cam Hart and Rick Lovato also appear on the report. The team will need to trim the list as it prepares for the Giants.

Fantasy managers should monitor practice notes closely; Becton’s status and Bozeman’s DNP could push early-season depth into relevance, while Jackson and Molden could unlock more favorable matchup ceilings in the Chargers’ secondary. Slater’s injury history adds another layer to roster decisions, and Denver’s prior win serves as a reminder of the Chargers’ potential ceiling and volatility heading into Week 4.

In sum, the Chargers enter Week 4 with a cloud of injury-related uncertainty that could tilt protection schemes, rotation roles, and fantasy upside as they face a tough Giants test.

Chargers head east to face the winless Giants with a favorable setup for fantasy managers. Through three weeks, LA sits among the league’s top units in total and passing yards, while New York’s defense has been torched, especially through the air. Omarion Hampton appears primed for a 100-yard rush day as the running game benefits from a vulnerable Giants front, and WRs Quentin Johnston and Keenan Allen should continue to pace the receiving corps.

Defensively, the Chargers have been stingy, limiting both yards and points, setting the stage for a disciplined game script. If Justin Herbert can exploit the Giants’ soft rush and secondary, Los Angeles should push toward 4-0. Fantasy players might target Herbert, Hampton, and the Chargers’ pass-catching trio, while the Giants’ skill players carry a high-risk, high-reward profile in this matchup.

Chargers visit Denver in Week 3 with momentum, chasing the AFC West lead as favorites to win the division. A win would keep LA atop the pile and move the betting line again in their favor.

Omarion Hampton is starting to push into a bigger role behind Najee Harris. Despite modest two-game numbers (3.1 YPC), his pass protection and opportunity first step could unlock a larger ground game if Week 3 goes in his direction.

Donte Jackson has been sticky in coverage since arriving as a 2025 free agent, allowing under 20 yards on 10+ targets. Tarheeb Still also stands out, with two passes defended and eight run stops, giving the Chargers a credible edge vs Denver’s pass attack.

Broncos’ discipline hasn’t matched the Chargers’ hot start, and LA’s home opener vibe could swing the tilt. The game sets up as a key barometer for divisional dynamics and fantasy outputs across backfields, corners, and playmakers.