Chargers vs. Raiders on Monday Night Football opens Week 2 and sets the AFC West tone without Patrick Mahomes. Justin Herbert exploded in Week 1 with 318 yards and 3 TDs, controlling the Chiefs game in Sao Paulo, while Geno Smith surged for 362 yards in the Raiders’ win in Foxboro. Vegas flashed a stingy run defense, and LA impressed with Herbert’s command. Injuries loom as Perryman, Tarheeb Still, Elijah Molden and Del’Shawn Phillips are listed as questionable, and betting markets show a tight spread and a low-mid 40s total.

Fantasy implications center on Herbert and Smith as top two-pass options, with Crosby anchoring a big-game ceiling for the Raiders’ defense and Perryman and Still potentially altering the Chargers’ frontline. The game at Allegiant Stadium carries heavy divisional weight, with Chargers favored by around 3.5 and a 46.5-point over/under, prompting savvy managers to weigh pass-heavy rosters, streaming defenses, and shot-clock timing for keyMonday-night lineups.

Injury chatter and line movement will drive late-week decisions. If Perryman or Still sit, expect upticks for Chargers linebackers and Raiders receivers in daily formats. Deep leaguers should monitor game flow—Herbert’s air attack versus a Raiders defense that zeroed in on the run could yield multiple high-leverage fantasy returns for the LA offense, while Smith’s volumes could sustain flexible captain options.