Buffalo at Baltimore in Week 1 sets early fantasy floors. Buffalo rode a league-best turnover differential in 2024 and did not commit a turnover in either 2024 meeting with Baltimore. James Cook tied for the NFL rushing TD lead with Derrick Henry (16), a mark that underscores both teams’ ground-game upside. Baltimore counters with Lamar Jackson’s explosive rushing and the edge-rush of Kyle Van Noy, plus Henry joining the Ravens’ backfield. Expect Cook and Allen to shape Week 1, with Henry and Van Noy looming as key pivots in lineups.

Historical matchups show Bills dominance in postseason meetings, while the Week 1 stage will reveal early-season fantasy leverage for Cook, Allen, and Baltimore’s backfield. Stay close on Kerr’s plan for Ravens’ run-fit and Buffalo’s ball-security discipline to gauge early season ceilings and risk in this marquee clash.