The Los Angeles Chargers have high hopes for their 2025 draft class, particularly three rookies poised to make significant impacts. First-round pick Omarion Hampton, a running back, is seen as being on the verge of a starting role, despite competition from veteran Najee Harris. The Chargers' new offensive scheme, led by Greg Roman, might initially favor Harris, but Hampton's talent could see him taking the reins before midseason.

Second-round receiver Tre Harris faces a challenge in unseating established starter Mike Williams. Although his limited route tree at Ole Miss raises concerns, he has shown potential with explosive plays. On the defensive side, third-round pick Jamaree Caldwell is in a competitive nose tackle race, but his high motor and versatility across the line give him a shot at starting. With development, these rookies could play pivotal roles in the Chargers' playoff pursuits.