The New England Patriots made significant adjustments following the 2025 NFL Draft, trimming their roster to comply with the 90-man limit. Six players were released, including offensive lineman Jake Andrews, who had an injury-plagued tenure after being drafted in 2023. Defensive lineman Marcus Harris, who spent last season on the practice squad, and wide receiver JaQuae Jackson, who struggled with injuries after being signed from the Falcons, were also cut. Linebacker Titus Leo, safety Mark Perry, and tight end Giovanni Ricci rounded out the list of departures.

Andrews, despite being a fourth-round pick, faced setbacks with a torn meniscus. Harris's failed bid to secure a spot on the active roster leads to his release, while Jackson's initial promise could not overcome the challenges posed by injury. Each player's release reflects the Patriots' need to refine their roster strategy after the draft.