Brock Purdy’s Week 3 availability is the central question for the 49ers as toe and shoulder issues collide with a home matchup against Arizona. A limited practice window keeps Purdy in play, but San Francisco has Mac Jones ready if Purdy can’t go. The team also navigates McCaffrey’s calf/rest schedule, Bosa and Williams’ vet days, and Jennings/Juszczyk injuries, while Ben Bartch lands on IR and rookie Connor Colby steps in at left guard.

Fantasy managers should monitor Purdy’s status; if he starts, the offense maintains a reasonable floor with potential upside in a plus matchup. If Jones starts, San Francisco shifts to a more conservative plan with McCaffrey as the centerpiece and Colby stabilizing the line for a run-focused attack against Arizona.

The 49ers bolster interior DL depth by re-signing Evan Anderson to the practice squad after he cleared waivers, a move that could anchor a deeper rotation in Year 2. Anderson logged 24 tackles, 1.0 sack and 267 defensive snaps across 12 games as a rookie and now returns to SF’s stack. The club also claimed Jordan Jefferson from Jacksonville to add interior push. On offense, SF filled out PS groups with Marquez Valdes-Scantling, Adrian Martinez and Sincere McCormick, enhancing WR, QB and RB depth ahead of the season.

These moves signal a plan to keep a robust pipeline for injuries and matchup-based rotations, especially along the defensive line where questions linger around interior production. The 49ers still face roster math to clear space, but the core intent is clear: more reliable depth and more flexible options across multiple packages and situations.

Meanwhile, the linked note about Jauan Jennings hints at contract questions as SF charts its long-term core, adding intrigue to how this PS abundance might influence future cap decisions and on-field roles during the grind of a full season.

San Francisco’s 2025 practice squad spotlights camp standouts and a pair of likely signings who could swing fantasy odds this year. Adrian Martinez, Sincere McCormick, Robbie Chosen, Drake Nugent and Eli Apple anchor a depth chart built to contribute behind the active roster, with Nugent and Nick Zakelj adding interior line flexibility and Chosen offering veteran pass-catching upside. This mix signals SF’s plan to weather injuries and suspensions, a smart angle for fantasy managers tracking late-season surges.

For fantasy and bets, Martinez and McCormick stand out as potential late-season inputs, while Nugent and Apple provide stabilizing floor for SF’s rotation. Bergen’s presence adds a special-teams lift, and Nugent’s preseason showing hints at a longer arc for interior depth. Watch how SF leverages this group when Week 1 rolls around and injuries test the depth chart.

Saints cap realities and a thin youth pipeline define 2025. Foskey was cut after two sackless seasons, Bresee is the lone 2023 draftee with a real role, and Miller flashed in the preseason though durability is a concern. Shough hasn’t seized the starting job, and a Devaughn Vele trade signals short-term moves. With 2026 cap trouble looming and the 2025 draft thin, New Orleans faces a long rebuild, with Olave as a rare bright spot guiding fantasy expectations.

Fantasy angles pivot on Bresee’s development, Miller’s durability, and any breakthrough from the Saints’ developing talent. If the club pursues a 2026 QB, stash targets around the offense and monitor cap-driven roster shifts that could create late-season value in a harsh year.