Arizona’s 22-21 home loss to Tennessee ranks as the franchise’s worst in Arizona history, a collapse from a 21-6 fourth-quarter lead. A late sequence featuring Emari Demercado’s nullified TD, Dadrian Taylor-Demerson’s pick that caromed into a Titans TD, and a 38-yard Ridley grab set up Joey Slye’s game-winning 29-yard field goal as time expired.

The loss exposes glaring mental-m toughness issues, with Calais Campbell urging a true fighter response and coach Jonathan Gannon acknowledging this would rigorously test the team’s resolve. For fantasy owners, the Демercado miscue looms large, while Ridley’s big play potential remains a silver lining as Tennessee survives a stumble-prone night.

Week 5 starts hinge on volume and matchup. Rachaad White steps into the lead back role for Tampa Bay with Bucky Irving out, offering solid flex upside in a favorable matchup vs Seattle. Pollard remains the Titans’ workhorse until Tyjae Spears returns, keeping him in flex territory. Kenneth Walker III faces a stout run defense and a backfield committee, making him a low-end RB2 with punt-punt upside via receiving work. Keenan Allen projects heavy targets against Washington, while Calvin Ridley and Ja’Marr Chase remain high-end options in shootouts. Sean Tucker is a speculative stash behind White, Luke McCaffrey’s role is uncertain, and Cooper Kupp stands as a must-start.

Overall, the Week 5 landscape favors high-volume pass-catchers and disciplined runners in clear roles. The Who Should I Start tool helps parse four-player comps, factoring scoring formats and byes to surface the best starts. Monitor injuries and game-flow specifically for Spears, Irving, and any last-minute Washington adjustments for Allen and Ridley, then lock in your lineup with confidence.