Calvin Ridley suits up for Tennessee as Tyjae Spears returns from IR in a clash with the Cardinals. Bryce Oliver is out, James Proche II inactive, and several Titans options sit on the sideline, squeezing the pass game into Ridley and the rest of the WR corps. Ridley has 141 yards on 24 targets this season with no TD, while the Titans chase a spark against a Cardinals squad that’s 2-2.

Week 5 carries notable lineup shakes for Titans–Cardinals. Calvin Ridley is listed active for the Titans clash, with Tyjae Spears also active and Kevin Winston Jr. set for his Titans debut. A cluster of Titans blockers and receivers are inactive, thinning the depth chart. For Arizona, Xavier Weaver sits out along with several linemen and defenders, narrowing the Cardinals’ pass-catch and blocking options. Fantasy managers should watch Spears’ workload and Ridley’s involvement for Titans, while assessing Cardinals’ WR depth behind Weaver and the impact of OL/inactive players on their play-calling.

Week 4 in Houston features the Tennessee Titans leaning on a depleted offensive line, with Dan Moore Jr. active despite lingering illness. JC Latham sits again, opening Oli Udoh to start at right tackle as Zeitler returns to guard alongside Cushenberry and Skoronski. Several Titans veterans are inactive across the line and at receiver, while the safeties Woods, Diggs, and Hooker anchor the back end in a matchup that's likely to test Titans’ protection and run game early.

Week 4 in Houston vs. Tennessee brings clear fantasy angles from early-injury shuffles. Stingley Jr. is active, anchoring a Texans secondary while Pierce and Berrios sit. Houston leans on Blake Fisher at left tackle as Cam Robinson sits. Titans’ JC Latham, Samuel Womack, John Ojukwu and Bryce Oliver are inactive, tightening up protection and elevating run-first looks for Tennessee. Stingley’s return could corral Titans’ aerials, while Texans’ WRs benefit from Berrios’ absence without Pierce.

Titans' pass protection remains a sore spot early in 2025, surrendering 15 sacks and 40 pressures through three games. Bill Callahan blames tough opponents, interdependent offense, and injuries rather than a lone unit. Week 4 pits Tennessee vs Houston’s edge duo Will Anderson Jr. and Danielle Hunter, testing Cam Ward as backups Oli Udoh and John Ojukwu try to steady the line. Fantasy takeaway: expect quick throws and chipped protection while monitoring Ward and downfield targets.