The Titans head into Week 2 vs. the Rams with a noticeable injury cloud on the depth chart. Four players were sidelined after the first practice: Quandre Diggs (hand), JC Latham (hip), Kalel Mullings (high ankle), and T'Vondre Sweat (ankle).

Diggs logged 31 defensive snaps in Week 1, while Latham started on the line and Mullings appeared in preseason and Week 1. Sweat has been limited after a tonsillectomy and an ankle issue. Oli Udoh could slot in for Latham if the hip lingers, testing the Titans’ offensive line and backfield depth.

Linebacker Arden Key, cornerback L'Jarius Sneed, and rookie Kevin Winston Jr. were limited in practice, signaling that Tennessee’s depth players may be leaned on if injuries persist. Health remains a priority as the Titans prepare for the Rams and fantasy managers watch for any pivots in personnel.

Stay tuned for updated practice notes, especially around Diggs, Mullings, and Sweat, since any downgrade could amplify opportunity for backups in a pivotal Week 2 clash that could shape early-season fantasy projections.

Amani Hooker’s three-year, $48.6 million extension with Tennessee locks in a playmaking safety who logged 96.2% of defensive snaps last season, piling up a career-high five interceptions and nine pass breakups. With Hooker returning as a starter, the Titans pair him with veteran Xavier Woods to fortify the back end, while Quandre Diggs provides rotational coverage and depth behind a five-safety slate. Week 1 at Denver will test a revamped unit that fantasy managers should watch for immediate IDP upside.

The deal signals a long-term commitment to a high-floor secondary, as Hooker’s consistency and ball skills translate into steady tackle and turnover potential. Woods’ arrival adds veteran presence; Diggs' rotational role keeps fresh looks in subpackages. Behind them, Mike Brown and 2025 third-rounder Kevin Winston Jr. add depth as Tennessee gauges development. Denver looms as a stern early-season gauge for the Titans’ defensive backfield.