Week 2 fantasy lineups hinge on clear roles and favorable matchups. Garrett Wilson should soak up targets against Buffalo, while Travis Etienne Jr. benefits from Tank Bigsby’s trade leaving him with extra touches in Jacksonville. Calvin Ridley’s volume remains solid despite a tougher matchup, and D.J. Moore projects steady targets facing Detroit. Marquise Brown could command looks with Kansas City short on WR depth, creating upside as a viable start in many leagues.

The article also highlights a powerful start/sit tool to compare up to four players, plus a snapshot of popular Week 2 searches. It emphasizes leveraging weekly projections, matchup data, and scoring formats to set optimal lineups for the 2025 season.