Tennessee fell to 0-3 in a 41-20 setback to Indianapolis after a dramatic start that included a Cam Ward pick-6. Ward rebounded with 219 passing yards and a TD, while Elic Ayomanor and Tony Pollard offered bright spots for fantasy managers amid an injury-plagued, inconsistent offense. Ridley struggled with drops, and the defense surrendered big plays, leaving fantasy lineups needing sharper adjustments as the Colts extended their early-season streak.

With Brownlee Jr. out and a shaken Titans defense, the offense leaned on Ward's growth and Ayomanor's rising connection, but the overall attack remains fragile. The Colts dominated early and never let up, pushing Indy to 3-0 and forcing the Titans to reevaluate personnel, targets, and play-calling as they plot a path to their first win of the year.