Kevin Winston Jr. won't debut in Week 1 as the Titans open the 2025 season against Denver. L'Jarius Sneed is active, bolstering a Titans secondary as they kick off in Denver on Sept. 7. Winston’s absence pressures Tennessee’s safeties and depth players, while Sneed’s availability could stabilize the back end early in the year. Fantasy managers should watch how Tennessee distributes snaps among reserve safeties and corners, as the Broncos test the unit with multiple receiver looks.

In this opener, depth, rotation and matchup-leaning roles become critical for Week 1 decisions. With Winston sidelined, the Titans will lean on veteran presence and opportunistic plays from the depth chart, while Sneed’s activation could anchor critical downs and limit big plays by Denver. The result will influence streaming targets and insurance plays for both defenses and secondary players in the early fantasy slate.

Overall, the Week 1 environment emphasizes depth over star power and immediate roles over long-term predictions. Sharp fantasy managers will track snap counts, delineations in the safety and corner groups, and the ways Denver exploits those matchups on Sunday afternoon.