Week 5 spotlight on the run game: Teair Tart paced interior defenders with a 94.9 run-defense grade, a forced fumble, and two run stops for the Chargers, underscoring elite interior disruption. Andrew Thomas returned healthy for the Giants with a 91.8 run-blocking grade, the highest Giants mark this season. Across the league, top run blockers and run defenders from Lions to Titans highlighted which players and teams to trust for in-season stats, fantasy projections, and betting angles.

Colts visit Raiders in Week 5 with Indianapolis riding a 3-1 surge led by Jonathan Taylor, while Las Vegas fights to stay in playoff contention. The clash in the trenches shapes the game: Jonah Laulu vs. Quenton Nelson, DJ Glaze vs. Laiatu Latu, and the Buckner-Stuart duo trying to flood the Raiders’ interior. Las Vegas’ improved interior run blocking from Parham, Meredith, and Powers-Johnson will be tested by Indiana’s big men, and Miller’s IR status adds uncertainty up front. Expect heavy ground work and pivotal line play that could swing fantasy value for both sides.

Raiders' offensive line woes come into sharp focus as a young unit learns on the job behind Kolton Miller. Breer's take centers on Powers-Johnson, Glaze, and Parham, noting Week 1 success gave way to a run game under 3.5 yards per carry and Geno Smith taking eight sacks. The path to improvement hinges on Powers-Johnson finding a scheme fit and the center’s pivotal role in the trench throttle, with patience urged until the line stabilizes.

Raiders sit at 1-2 as frustration grows, but the insiders stress patience and a measured path forward. Pete Carroll pushes stability, testing Jackson Powers-Johnson at center while the rest of the line fights for cohesion. Brock Bowers’ brace, Michael Mayer’s illness protocol, Caleb Williams’ elite talent, and Rome Odunze’s burgeoning role pepper the conversation, shaping early-season fantasy and betting angles around line decisions, health timelines, and high-upside targets.