Week 6 fantasy RBs hinge on snap-driven risers: Kimani Vidal seizes the Chargers' backfield after Omarion Hampton's injury, while Isaiah Bond widens his Browns workload with rising route participation and targets as Cleveland pushes tempo. Kamara's workload fades in New Orleans as Kendre Miller surges, and Jameson Williams' target share remains volatile in Detroit. A broad list of honorable mentions—Henderson, Downs, Legette, Davis, Mostert, Bech, Mitchell, Dulin, Blue—offers deeper flex as byes loom.

Rome Odunze is on a tear, pushing toward the Bears' single-season receiving TD record as he sits with five scores in four games. Calibrated with Caleb Williams, he looks like a weekly anchor in red-zone and big-play scenarios, making fantasy managers circle him as a must-start option down the stretch. Chicago’s plan revolves around him, and if health cooperates, Odunze projects an uptick that could push him into historic Bears territory.

The rest of the season could bring a running back upgrade for Chicago as GM Ryan Poles eyes help on the ground. A midseason swap for a veteran back could unlock the offense’s ceiling, easing the load on Williams and Odunze while stabilizing the rushing attack. Austin Booker’s return could alter the pass rush and the defensive tempo, too.

On defense, Kevin Byard is playing at a high level, with secondary reinforcements on the way from injury. If Taj Edwards and Kyler Gordon return healthy, the back seven could improve enough to help the whole unit, including Booker who could lead the team in sacks upon activation. Cairo Santos has demonstrated reliability and could further extend his range, potentially hitting a career-long kick this year.

Ashton Jeanty erupted for 138 rushing yards on 21 carries and scored three times, sparking a breakout in a Raiders loss to Chicago. He also added two receptions for 17 yards, and his return to a natural stance unlocked burst that dwarfed his prior totals. The performance highlighted a potential ceiling in Las Vegas’ backfield, especially with Raheem Mostert providing a complementary punch.

Coach Pete Carroll praised the line and Jeanty’s burst, noting the heavy run volume and clean protection that fueled the day. The Bears’ defense couldn’t slow the two-back look, setting a blueprint for the Raiders going forward and prompting fantasy managers to revisit Jeanty’s upside in the weeks ahead.

Ashton Jeanty erupted for 155 yards from scrimmage and three touchdowns in Week 4 against the Bears, flashing both burst and receiving chops to anchor a breakout performance. A 64-yard rushing score and two receiving touchdowns showcased his dual-threat upside, elevating his fantasy value from sleeper to potential weekly flex play.

The breakout could reshape Vegas’ backfield dynamics, with Raheem Mostert remaining a threat but Jeanty showing the juice to command a larger role. Bears’ run defense had been porous, amplifying the moment, but Jeanty’s efficiency (6.6 YPC) and big-play ability set up a real, longer-term fantasy case if the Raiders ride the hot hand.

Jeanty now tops Week 4 rushing yards among RBs (138) and sits among the league’s most efficient backs (RYOE noted by Next Gen Stats). With Omarion Hampton posting elite early-season metrics elsewhere, the rookie’s breakout could be the spark Vegas needed to diversify its offense and give fantasy managers a legitimate late-season swing option.