Denver's middle remains the weak point through two games, with Strnad and Singleton vulnerable to hybrid looks as Colts targets sliced through the space. A potential fix hinges on Dre Greenlaw's health, though his status is uncertain and Denver has few easy answers on short notice. Payton has leaned into a run-first approach, setting up a Week 3 test against the Chargers that will probe whether disguises and depth can stabilize the interior.

For fantasy managers, the takeaway is risk around the Broncos’ linebacking corps against backfield and tight-end weapons. If Greenlaw can play, the defense gains an important anchor; if not, look for continued rotation, more zone looks, and a heavier workload for Strnad and Singleton to limit mismatches in the middle.