Denver's offensive line vaults to No. 1 after a Week 4 performance that yielded six pressures and zero sacks on 45 pass plays, driving a 93.3 PFF pass-blocking efficiency that sits among the league’s elite. Bolles leads the unit with an 88.1 overall grade, while Powers and Meinerz anchor the interior with exceptional pass-game consistency. Week 5 projections reinforce the starting five of Bolles, Powers, Wattenberg, Meinerz, and McGlinchey as a unit that fantasy managers should watch closely.

Buffalo rises with strong run protection and a revamped forward wall. Van Demark’s 82.0 run-blocking grade tops the Bills, complemented by Edwards’ 75.3 overall grade and Dawkins’ 77.8, both ranking highly among guards and tackles. The shift comes as Cincinnati’s defense faced a tougher challenge and Philly’s line wobbled, underscoring how weekly OL play shapes fantasy output for both quarterbacks and backs in a league where clean pockets remain king.

Four weeks in, PFF’s award panel zeroes in on the NFL’s early leaders. Matthew Stafford tops the QB grade among those with 50-plus attempts and boasts the league’s strongest big‑time throws rate. Puka Nacua stands out as a record‑centered target with elite receiving metrics. Micah Parsons vaults to the top of edge rush metrics, while a slate of rookies and protectors populate the latest All‑Pro conversations. The piece lays out the Week 5‑ready fantasy implications across offense, defense, and special teams.

Stafford and Nacua anchor the Rams’ spotlight, with Parson’s disruptive profile propping up a distinctive defensive case. Emeka Egbuka and Carson Schwesinger emerge as noteworthy rookie standouts on offense and defense, while Garett Bolles locks down one of the league’s premier pass protections. The compilation also flags second‑team accelerants and sleepers who could swing value in weekly lineups as the season unfolds.