Denver heads to Philadelphia in Week 5 with a sharpened run game thanks to Nate Adkins’ return and Quinn Meinerz back at guard, while Lucas Krull is out. Engram and Trautman provide reliable TE targets, and Adkins’ clearance keeps the offense balanced as Marvin Mims Jr. and Alex Singleton contribute in the receiving and tackling roles. The Eagles counter with Nakobe Dean OUT and Jihaad Campbell back, but questions linger around Dallas Goedert, Jalen Carter, and Lane Johnson. The clash could hinge on Denver’s ground attack volume and Philadelphia’s midseason adjustments.

Krull is headed to injured reserve with a foot fracture, sidelining him for a minimum of four games. Denver will lean on Evan Engram, Adam Trautman and Nate Adkins at tight end as the offense navigates a short week and a long trip to London. Meinerz’s return stabilizes the line, while Roach and Sanders remain on IR. A road swing from Philadelphia to Tottenham against the Jets heightens the TE role and adds a concrete path for fantasy gains in the near term.

London’s high-stakes setup amplifies any TE targets, making the Denver trio a focal point in two-TE sets and in red-zone avenues. The immediate fantasy implication centers on who grabs the most consistent snaps and looks, with matchup-driven upside depending on game script and opponent pressure in a tight, travel-heavy slate.

Denver's offensive line vaults to No. 1 after a Week 4 performance that yielded six pressures and zero sacks on 45 pass plays, driving a 93.3 PFF pass-blocking efficiency that sits among the league’s elite. Bolles leads the unit with an 88.1 overall grade, while Powers and Meinerz anchor the interior with exceptional pass-game consistency. Week 5 projections reinforce the starting five of Bolles, Powers, Wattenberg, Meinerz, and McGlinchey as a unit that fantasy managers should watch closely.

Buffalo rises with strong run protection and a revamped forward wall. Van Demark’s 82.0 run-blocking grade tops the Bills, complemented by Edwards’ 75.3 overall grade and Dawkins’ 77.8, both ranking highly among guards and tackles. The shift comes as Cincinnati’s defense faced a tougher challenge and Philly’s line wobbled, underscoring how weekly OL play shapes fantasy output for both quarterbacks and backs in a league where clean pockets remain king.

Denver’s offense clicked behind a refreshed two-back rhythm from J.K. Dobbins and RJ Harvey, totaling 203 yards and a touchdown on 35 touches in a 28-3 win. The series-by-series approach unlocked both backs and sharpened the run game, setting up a tougher road slate ahead.

Defensively, the Broncos throttled Cincinnati, while Talanoa Hufanga and Pat Surtain II eroded the Bengals’ top targets. Bo Nix managed late-chaos effectively, Sutton cashed in, and the blocking from Pat Bryant opened lanes. The win primes Denver for October tests and keeps fantasy angles buzzing into Philadelphia.