Bo Nix faces a suddenly tough Indianapolis defense, which limited big-passing outputs in Week 1. Nix’s dink-and-dunk profile—4.4 yards per attempt and a notably low depth of target—keeps him outside the top-15 projection this week, suggesting a cautious fantasy approach unless you’re chasing a high-floor, low-ceiling streamer.

Daniel Jones burst Week 1, but a tougher Denver unit awaits, and the game carries a 42.5 over/under, signaling limited scoring. Jones likely won’t replicate his ceiling, making him a riskier play in standard formats. Rodgers faces Seattle’s pressure-heavy plan, which could curb his upside, while Tua Tagovailoa’s Week 1 showing against Indianapolis offers a reminder that matchup matters even for high-powered offenses.

Colts defense allowed the fourth-fewest passing yards in Week 1 and held Tua to sub-6 fantasy points, underscoring why this week’s games tilt toward cautious lineups and safer bets at quarterback. The overall tone is to temper expectations for high-ceiling weeks and lean on safer floor options wherever possible.