Five bold Week 2 predictions for Denver vs. Indianapolis shape a fantasy-friendly path: a 200+-yard rushing onslaught with one back eclipsing 100 yards; Bo Nix climbs to 70% completions with 200 passing yards, a touchdown and no interceptions, while the offense emphasizes the run early. Denver’s defense eyes a six-sack performance from different players, including a secondary contributor, plus three takeaways. Jeremy Crawshaw bumps to a 49.5-yard punt average on a handful of tries, while Payton’s plan leans into ball control and field-position leverage.

The Colts’ run defense is vulnerable, even as their pass defense shines; if Denver can sustain the ground game, the game plan should unlock better efficiency for Nix and keep the chains moving. The piece uses a Giants scenario to illustrate pressure-induced turnovers, underscoring how the Broncos’ defense and special teams could swing outcomes in a close contest. For fantasy bettors, focus on the running back workload, Nix’s efficiency, sack distribution, and Crawshaw’s punting windows.