Buffalo Bills host the Miami Dolphins in Thursday Night Football as Week 3 opens, with Buffalo riding a 2-0 start and Miami slumping 0-2. Bills are the heavy -13.5 favorite, and the slate features two undefeateds in Philly vs Los Angeles and Arizona vs San Francisco. Giants vs Chiefs caps Sunday Night, while Lions visit Ravens on Monday Night Football. The full card lists every Week 3 game with lines, totals, and FPI odds to guide fantasy lineups and bold bets.

Fantasy emphasis centers on exploiting high-scoring expectancies and favorable game scripts. Track line moves and totals for starts like top offenses and potential shootouts, while identifying mid-range sleepers in games with clear target volume or pace advantages. Use the odds and projections to balance upside with risk as Week 3 decisions tighten.

Week 2’s fantasy seesaw leaned toward Daniel Jones and Wan’Dale Robinson in New York, and Juwan Johnson in New Orleans, with Spencer Rattler’s passing volume rising. Jones has been precise and the Robinson breakout gives the Giants a real Week-3 ceiling. Johnson’s red-zone usage hints at a top TE floor in the early going.

Lawrence faced a rough day; Harvey’s Broncos backfield remains crowded; Khalil Shakir’s role is uncertain; Kupp rebounded after a rocky opener, underscoring Week 2’s volatility and the need to chase hot hands weekly.

Six QBs threw for 300+ yards in Week 2, led by Russell Wilson's 450-yard night against Dallas, with Jared Goff tossing five TDs and Lamar Jackson adding four. Allen and Hurts disappointed, while Joe Burrow’s foot injury clouds Week 3. The waiver wire focus centers on under-65% rostered passers and a couple of deep two-QB sleepers. Week 3 streaming paths span 1QB, 2QB, and superflex formats, with Browning serving as a prominent Bengals option when Burrow’s status is uncertain.

This guide breaks down the top Week 3 pickups, stash targets, and matchup-aware thresholds, translating Week 2 fireworks into actionable roster moves for savvy managers. It emphasizes balance between upside and roster cost, plus the evolving dynamics of QB depth in 2025 leagues.