Denver heads into the opener with key front-seven absences. Dre Greenlaw is ruled out with a quad issue, and Malcolm Roach is sidelined by a Grade 2 calf strain that could cost several weeks. Denver is leaning on Justin Strnad to anchor the middle, with Karene Reid and Levelle Bailey factoring into the rotation as the team contemplates elevating Bailey from the practice squad. Expect Eyioma Uwazurike and Jordan Jackson to shoulder more interior duties as the Broncos adjust on the fly.

With Roach potentially missing extended time, the run defense and interior pressures will hinge on Uwazurike’s burst and Jackson’s ability to hold the point. Nate Adkins is out, and Dondrea Tillman was limited, so the depth chart tightens and fantasy managers in IDP leagues will want to monitor snap shares closely as Week 1 unfolds.